A couple months ago, i tried serrapeptase for a couple of weeks. I thought it was helping and was about to write a post on here about it. However, my family got a GI bug which I eventually contracted. The pain, vomiting and diarrhea was so bad I went to the ER. Eventually got over the bug and started to take the serrapeptase again. I ended up having the same severe pain, nausea and diarrhea 2 hours after I took the serrapeptase. My wife started googling serrapeptase and apparently it can cause severe GI "allergic" reactions. Turns out I never had a GI bug but was having a severe reaction to the serrapeptase enzyme. I would read the reviews and understand it may cause SEVERE GI upset. Otherwise, I would give it a shot because some people swear by it. I'm too afraid to try the other enzymes because of the reaction I had.